首页> 外文OA文献 >A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.

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A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.

机译：用具有糖蛋白K和膜蛋白UL20突变的HsV-1 VC2病毒对小鼠进行单次肌肉内疫苗接种赋予针对强毒性HsV-1和HsV-2毒株的致死性阴道内攻击的全面保护。

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Brent A Stanfield; Jacque Stahl; Vladimir N Chouljenko; Ramesh Subramanian; Anu-Susan Charles; Ahmad A Saied; Jason D Walker; Konstantin G Kousoulas;
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1. Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses [J] . Arun V Iyer, Bapi Pahar, Vladimir N Chouljenko, Virology Journal . 2013,第1期

机译：单剂量糖蛋白K（gK）缺失的HSV-1减毒活病毒保护小鼠免受HSV-1和HSV-2的致命性阴道攻击，并诱导持久的T细胞记忆免疫反应
2. A Herpes Simplex Virus (HSV)-2 Single-Cycle Candidate Vaccine Deleted in Glycoprotein D Protects Male Mice From Lethal Skin Challenge With Clinical Isolates of HSV-1 and HSV-2 [J] . Burn Clare, Ramsey Natalie, Garforth Scott J., The Journal of Infectious Diseases . 2018,第5期

机译：在糖蛋白D中缺失的单纯疱疹病毒（HSV）-2单循环候选疫苗免受HSV-1和HSV-2的临床分离株免受致死皮肤攻击的致命皮肤攻击
3. Protection from Herpes Simplex Virus (HSV)–2 Infection with Replication-Defective HSV-2 or Glycoprotein D2 Vaccines in HSV-1–Seropositive and HSV-1–Seronegative Guinea Pigs [J] . Yo Hoshino1 Lesley Pesnicak1 Kennichi C. Dowdell1 Peter D. Burbelo2 David M. Knipe3 Stephen E. Straus1 and Jeffrey I. Cohen1 Journal of Infectious Diseases . 2009,第7期

机译：HSV-1血清阳性和HSV-1阴性豚鼠的复制缺陷型HSV-2或糖蛋白D2疫苗可预防单纯疱疹病毒（HSV）-2感染。
4. A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains [O] . Brent A. Stanfield, Jacque Stahl, Vladimir N. Chouljenko, 2010

机译：用糖蛋白K和膜蛋白UL20突变的HSV-1 VC2病毒对小鼠进行单次肌内疫苗接种可完全保护其免受强毒HSV-1和HSV-2菌株的致命性阴道内攻击。
5. Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis [O] . Shan K. Naidu, Rafiq Nabi, Nagarjuna R. Cheemarla, 2020

机译：用人疱疹病毒型-1（HSV-1）VC2疫苗的小鼠肌内接种，但不是其亲本菌株HSV-1（F）赋予全面保护致死眼HSV-1（McKrae）发病机制

A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.

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